منابع مشابه
Critical Review Protecting Pancreatic b-cells
Type 1 diabetes mellitus is an autoimmune disorder in which the insulin-producing b-cells of the pancreatic islets of Langerhans are selectively destroyed. Transplantation of allogeneic islets offers a novel therapeutic approach for type 1 diabetic patients. Primary obstacles to the successful outcome of this treatment are loss of the islets occurring first during the isolation procedure and th...
متن کاملGlucolipotoxicity in Pancreatic β-Cells
The recent epidemic of type 2 diabetes in Asia differs from that reported in other regions of the world in several key areas: it has evolved over a much shorter time, in an earlier stage of life, and in people with lower body mass indices. These phenotypic characteristics of patients strongly suggest that insulin secretory defects may perform a more important function in the development and pro...
متن کاملFractalkine (CX3CL1), a new factor protecting β-cells against TNFα
OBJECTIVE We have previously shown the existence of a muscle-pancreas intercommunication axis in which CX3CL1 (fractalkine), a CX3C chemokine produced by skeletal muscle cells, could be implicated. It has recently been shown that the fractalkine system modulates murine β-cell function. However, the impact of CX3CL1 on human islet cells especially regarding a protective role against cytokine-ind...
متن کاملRole of MicroRNA in Pancreatic β-Cells
One of most intriguing discoveries in biology in recent years is unquestionably the identification of the family of small, noncoding RNAs known as microRNAs (miRNAs). Originally described in worms (1), miRNAs are now known to be virtually ubiquitous among vertebrates, including humans. Over 400 genes encoding miRNAs are dispersed throughout the human genome, many of them unexpectedly located wi...
متن کاملIntranuclear Rods in Pancreatic Islet Β-cells
In the course of ultrastructural studies on the morphology of the pancreatic islets of various rodent species used in current diabetes research, intranuclear rod-shaped structures were observed in the $-cells of mice . Since there appeared to be no previous reports on the occurrence of such structures in endocrine pancreas of any species, it was thought worth while to pay some further attention...
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ژورنال
عنوان ژورنال: IUBMB Life (International Union of Biochemistry and Molecular Biology: Life)
سال: 2004
ISSN: 1521-6543,1521-6551
DOI: 10.1080/15216540400006469